Comprehensive Services
We provide customers with an end-to-end service that is customized
to bring the project to success and typically includes LNP sample preparation, data collection, and
data analysis.
Cutting-Edge Techniques
We provide services for three of the most effective characterization techniques for LNPs: Cryo-EM, SAXS, and DLS.
Rapid Turnaround Times
Our well-optimized workflows enable you to get the information
you require at the right time, thereby accelerating your research.
Please, do not hesitate to contact us and find out how our Cryo-EM, SAXS and DLS services can support your innovative LNP-based therapeutics. Helix BioStructures is happy to be your partner in the development of novel drug delivery systems.
Milestone-based LNP Services
Grid Screening
Vitrify sample, capture small number of images representing thickness range, evaluate by eye for optimal particle mono-dispersity, density and morphology, and deliver report on recommended next steps.
Pilot dataset and processing
Collect ~500 micrograph movies, using the same conditions/setup as a full dataset; process data; and, if 2D processing goes well, proceed to 3D for deeper insight.
Full dataset collection and processing
To "Collect 5,000 to 15,000 micrograph movies over 24 hours (depending on grid type and collection parameters), and report on findings and expert analysis (final particle count, resolution, FSC curves, particle angular distribution, sharpening and local resolution). Also provide half maps, full map, sharpened map and sharpened map filters to local resolution.
Never feel lost in the process again
LNPs have become an essential delivery mechanism for RNA and other molecules in the pharmaceutical and agricultural industries. Characterizing LNPs allows researchers to develop and produce the most effective platform for delivering their next-generation molecules in an industrially efficient manner. At Helix, we offer in-depth knowledge and a multi-technique characterization approach for your LNP formulations.