Equipment
To fulfill its mission to make structural biology and protein production more accessible to the next generation of scientists, drug discovery and development companies, Helix puts the world's most advanced equipment within flexible, scalable, and affordable reach of its customers. Learn below about specific instruments and technologies that are available as part of co-sourcing.
A comprehensive inventory of our instruments
Microfluidics M-110P
Manufacturer
Microfluidics
Model
M-110P
Service Type
Protein Production
Specifications
- Operating Pressure: Up to 30,000 psi (207 MPa)
- Flow Rate: Adjustable, up to 200 mL/min
- Homogenization Capacity: 120 mL to 1 L per minute
Application
The Microfluidics M-110P is a high-pressure homogenizer designed for the efficient and consistent processing of nanoparticles, emulsions, cell lysates, and other complex biological materials. It utilizes high-shear forces generated by ultra-high pressure to break down particles to sub-micron levels, ensuring uniform particle size distribution and stable emulsions. This instrument is widely used in pharmaceutical development, biotechnology, and materials science for producing high-quality dispersions and achieving superior cell disruption.
Recommended Sample Requirements
- Sample Volume: 20 mL to 5 L, depending on the application.
- Viscosity: Suitable for low to medium viscosity samples.
- Particle Size: Best suited for starting particles of 100 nm to 10 microns.
- Temperature: Samples should be pre-cooled if temperature-sensitive, as homogenization can generate heat.
- pH Range: Compatible with a wide pH range (2-12) depending on the material.
Art Robbins Instruments Gryphon LCP
Manufacturer
Art Robbins Instruments
Model
Gryphon LCP
Service Type
X-ray Crystallography
Specifications
- Dispensing Volume Range: 100 nL to 10 µL
- Plate Compatibility: 96, 384, and 1536-well plates
- Operation Modes: Automated liquid dispensing, Lipidic Cubic Phase (LCP) setup
Application
The Gryphon LCP by Art Robbins Instruments is a versatile liquid handling system specifically optimized for the crystallization of membrane proteins using the Lipidic Cubic Phase (LCP) method. This automated system is designed to perform precise and reproducible dispensing of viscous lipidic materials and aqueous solutions into crystallization plates. It is commonly used in structural biology labs to streamline the setup of LCP crystallization trials, reducing manual errors and increasing throughput for protein crystallization experiments.
Recommended Sample Requirements
Art Robbins Instruments CrysCam
Manufacturer
Art Robbins Instruments
Model
CrysCam
Service Type
X-ray Crystallography
Specifications
- Camera Resolution: High-definition, up to 5 megapixels
- Imaging Modes: Brightfield and UV fluorescence
- Plate Compatibility: 96, 384, and 1536-well plates; standard SBS format
- Software: Integrated analysis software with image storage and annotation capabilities
Application
The Art Robbins Instruments CrysCam is a high-precision imaging system specifically designed for monitoring and analyzing protein crystallization experiments. Equipped with both brightfield and UV fluorescence imaging capabilities, the CrysCam allows researchers to capture clear images of crystallization drops, enabling detailed observation of crystal growth over time. It is an essential tool in structural biology labs for documenting and optimizing crystallization conditions, as well as identifying protein crystals among other precipitates.
Recommended Sample Requirements
- Crystal Size: Suitable for crystals as small as 10 µm in size.
- Plate Type: Compatible with standard crystallization plates (96, 384, 1536-well).
- UV Fluorescence: Samples containing aromatic amino acids or other UV-absorbing molecules.
- Temperature Stability: Crystallization drops should be stable at room temperature for imaging.
- Sample Volume: Works best with typical crystallization drop volumes, ranging from 50 nL to 10 µL.
SPT Labtech Mosquito XTAL3
Manufacturer
SPT Labtech
Model
Mosquito XTAL3
Service Type
X-ray Crystallography
Specifications
- Dispensing Volume Range: 25 nL to 1.2 µL
- Plate Compatibility: 96, 384, and 1536-well plates
- Precision: < 8% CV (Coefficient of Variation) across full volume range
- Pipetting Technology: Positive displacement with disposable tips
- Operation Modes: Serial dilution, backfill, LCP dispensing, seeding
Application
The SPT Labtech Mosquito XTAL3 is an automated liquid handling robot designed for high-throughput protein crystallization setup. Its highly accurate positive displacement technology ensures precise and consistent dispensing of nanoliter volumes, making it ideal for setting up complex crystallization experiments, including those involving difficult-to-handle viscous liquids such as Lipidic Cubic Phase (LCP). The Mosquito XTAL3 streamlines crystallization screening by minimizing sample waste, speeding up the setup process, and improving reproducibility.
Recommended Sample Requirements
- Protein Concentration: Works effectively with protein concentrations ranging from 0.1 mg/mL to 150 mg/mL.
- Viscosity: Handles a wide range of viscosities, including LCP and other viscous solutions.
- Sample Volume: Optimal for small-volume crystallization trials, from 25 nL up to 1.2 µL per drop.
- Temperature: Samples should be compatible with ambient or controlled room temperature during setup.
- Buffer Compatibility: Suitable for a broad range of crystallization buffers.
SPT Labtech DragonFly
Manufacturer
SPT Labtech
Model
DragonFly
Service Type
X-ray Crystallography
Specifications
- Dispensing Volume Range: 200 nL to 4 mL
- Plate Compatibility: 96, 384, and 1536-well plates; deep-well plates
- Precision: CV < 5% across all volume ranges
- Dispensing Technology: Non-contact, positive displacement dispensing
- Operation Modes: Reagent dispensing, gradient dispensing, serial dilutions, assay setup
Application
The SPT Labtech DragonFly is a highly versatile liquid handler designed for rapid and precise dispensing of reagents and samples across a wide range of volumes. It excels in applications such as assay development, high-throughput screening, and crystallization setups, providing consistent and accurate dispensing. The non-contact dispensing technology minimizes cross-contamination and dead volume, making the DragonFly particularly useful in labs where precision and efficiency are paramount. Its ability to handle a broad range of liquids, from aqueous solutions to viscous reagents, ensures that it meets the needs of various research workflows.
Recommended Sample Requirements
- Reagent Type: Suitable for a wide range of reagents, including aqueous solutions, DMSO, and viscous liquids.
- Volume Range: Ideal for applications requiring precise dispensing from 200 nL to 4 mL.
- Plate Types: Compatible with standard and deep-well plates, including 96, 384, and 1536-well formats.
- Temperature Stability: Samples and reagents should be stable at ambient or controlled room temperature.
- Viscosity: Capable of handling both low and high-viscosity liquids.
SPT Labtech MXOne
Manufacturer
SPT Labtech
Model
MXOne
Service Type
X-ray Crystallography
Specifications
- Throughput: Up to 600 samples per hour
- Sample Volume: 10 µL to 1 mL per sample
- Sample Capacity: Up to 1536 samples in a single run
- Plate Compatibility: 96, 384, 1536-well plates, and tube racks
- Pipetting Technology: Non-contact acoustic dispensing and positive displacement
Application
The SPT Labtech MXOne is an advanced liquid handling system designed for high-throughput sample preparation and assay setup in life science laboratories. The MXOne combines non-contact acoustic dispensing with positive displacement pipetting to ensure precise and accurate liquid handling across a wide range of volumes. This system is ideal for applications such as genomics, drug discovery, and biochemical assays where reproducibility and minimal sample waste are critical. With its high-speed processing and flexibility, the MXOne enhances laboratory efficiency by enabling large-scale experiments with consistent results.
Recommended Sample Requirements
- Sample Volume: Handles sample volumes ranging from 10 µL to 1 mL.
- Reagent Compatibility: Suitable for a variety of reagents, including aqueous solutions, DMSO, and other solvents.
- Plate Types: Compatible with 96, 384, and 1536-well plates, as well as tube racks.
- Temperature Stability: Samples should be stable at room temperature during processing.
- Viscosity Range: Effective for both low and medium viscosity liquids.
Leica M205C
Manufacturer
Leica Microsystems
Model
M205C
Service Type
X-ray Crystallography
Specifications
- Magnification Range: 7.8x to 160x
- Zoom Ratio: 20.5:1
- Resolution: Up to 0.952 microns
- Working Distance: 61.5 mm with standard objective
- Optics: FusionOptics technology for enhanced depth of field and resolution
- Illumination: Integrated LED illumination with adjustable intensity
- Eyepieces: 10x/22 mm, adjustable
- Camera Compatibility: C-mount for digital camera integration
Application
The Leica M205C is a high-performance stereo microscope that combines innovative optics with ergonomic design, making it ideal for a wide range of applications in research, quality control, and education. The M205C features Leica’s FusionOptics technology, which enhances depth of field and resolution simultaneously, allowing users to observe fine details with exceptional clarity. With its wide zoom range and integrated LED illumination, the M205C is perfect for tasks that require detailed observation, such as sample inspection, dissection, and documentation in life sciences and materials research.
Recommended Sample Requirements
Thermo Scientific Vitrobot Mark IV
Manufacturer
Thermo Scientific
Model
Vitrobot Mark IV
Service Type
cryo-EM
Specifications
- Cooling System: Liquid nitrogen-cooled ethane; cryo-plunge system
- Temperature Range: -180°C to ambient temperature
- Humidity Control: Adjustable between 70% and 100%
- Plunge Speed: Adjustable, with a maximum speed of 3 m/s
- Blotting Force: Programmable, ranging from 0 to 5 N
- Blotting Time: Adjustable, from 0.1 to 10 seconds
Application
The Thermo Scientific Vitrobot Mark IV is a precision cryo-plunging device used for preparing vitrified samples for cryo-electron microscopy (cryo-EM). It ensures the rapid and consistent freezing of biological samples by plunging them into liquid ethane, preserving their native structure in a thin layer of vitreous ice. The Vitrobot Mark IV is equipped with advanced humidity and temperature control to maintain optimal sample conditions, reducing the risk of ice crystal formation. This instrument is critical for researchers who require high-quality cryo-EM grids for structural biology studies.
Recommended Sample Requirements
- Sample Concentration: Ideal for samples concentrated at 0.5 mg/mL to 10 mg/mL.
- Sample Volume: Typically requires 3-5 µL per grid.
- Temperature Sensitivity: Suitable for samples that need to be vitrified at cryogenic temperatures.
- Buffer Compatibility: Compatible with common cryo-EM buffers, including those containing glycerol, sucrose, or other cryoprotectants.
- Grid Types: Compatible with standard TEM grids (copper, gold, molybdenum).
Ted Pella PELCO easiGlow
Manufacturer
Ted Pella, Inc.
Model
PELCO easiGlow
Service Type
cryo-EM
Specifications
- Glow Discharge Chamber Size: 100 mm diameter, 65 mm height
- Pressure Range: 0.1 mbar to 2.0 mbar
- Electrode Distance: Adjustable, typically 10 mm to 15 mm
- Voltage Range: 0 to 500 V DC
- Current Range: 0 to 5 mA
- Cycle Time: Adjustable from 10 seconds to 99 minutes
- Gas Requirements: Compatible with air, argon, or other inert gases
Application
The Ted Pella PELCO easiGlow is a compact, easy-to-use glow discharge system designed for the surface modification of TEM grids and other substrates. It is commonly used in electron microscopy sample preparation to make carbon-coated grids hydrophilic, improving the spreading of aqueous solutions and ensuring better sample adhesion. The easiGlow features adjustable parameters for voltage, pressure, and cycle time, allowing users to fine-tune the glow discharge process for various applications. Its small footprint and simple operation make it an essential tool in any electron microscopy lab.
Recommended Sample Requirements
- Substrate Type: Compatible with TEM grids, carbon films, and other substrates requiring surface modification.
- Gas Type: Operates with air, argon, or other inert gases for the glow discharge process.
- Sample Sensitivity: Suitable for sensitive samples that benefit from hydrophilization without excessive heat or damage.
- Pressure and Voltage Settings: Adjustable to accommodate different substrates and desired outcomes.
Cytiva Life Sciences ÄKTA go
Manufacturer
Cytiva Life Sciences
Model
ÄKTA go
Service Type
Protein Production
Specifications
- Flow Rate Range: 0.001 to 25 mL/min
- Pressure Rating: Up to 5 MPa (50 bar, 725 psi)
- Gradient Accuracy: ± 0.5% at 0.5 to 25 mL/min
- Sample Injection: Manual injection valve, autosampler compatibility
- Fraction Collector: Up to 96 fractions, compatible with a wide range of tube sizes
- UV Detection: Wavelength range: 190 to 700 nm, single-wavelength detection
- System Control: UNICORN software with real-time monitoring and control
Application
The Cytiva Life Sciences ÄKTA go is a compact and versatile chromatography system designed for protein purification at the laboratory scale. It is part of the well-established ÄKTA series, known for reliability and precision in biomolecular separations. The ÄKTA go is ideal for small-scale protein purification tasks, such as affinity, ion exchange, and size-exclusion chromatography. Its user-friendly UNICORN software provides robust control and monitoring of the purification process, making it an excellent choice for researchers who require consistent and high-quality results.
Recommended Sample Requirements
- Sample Volume: Suitable for small to medium sample volumes, typically up to 10 mL.
- Buffer Compatibility: Compatible with a wide range of aqueous buffers used in chromatography.
- Protein Type: Ideal for purifying proteins, peptides, and other biomolecules.
- Column Compatibility: Works with pre-packed columns and custom-packed columns for various chromatography techniques.
Cytiva Life Sciences ÄKTA pure
Manufacturer
Cytiva Life Sciences
Model
ÄKTA pure
Service Type
Protein Production
Specifications
- Flow Rate Range: 0.001 to 25 mL/min (can be expanded to 100 mL/min with pump upgrades)
- Pressure Rating: Up to 20 MPa (200 bar, 2900 psi)
- Gradient Accuracy: ± 1% across the flow rate range
- Sample Injection: Manual injection valve, autosampler, and sample pump options
- Fraction Collector: Accommodates up to 768 fractions, compatible with various tube and plate formats
- UV Detection: Dual-wavelength detection, 190 to 700 nm
- System Control: UNICORN software with extensive method programming, real-time monitoring, and data analysis
- Modularity: Highly customizable with optional modules for pH monitoring, conductivity, air sensors, and more
Application
The Cytiva Life Sciences ÄKTA pure is an advanced, fully customizable chromatography system designed for complex protein purification workflows. This versatile system supports a wide range of chromatography techniques, including affinity, ion exchange, hydrophobic interaction, and size-exclusion chromatography. The ÄKTA pure is ideal for research and development applications, offering flexibility in system configuration and method setup to accommodate different purification strategies. The system is controlled by the powerful UNICORN software, which provides comprehensive data handling, method programming, and process monitoring capabilities.
Recommended Sample Requirements
- Sample Volume: Suitable for a wide range of volumes, from microliter to liter scales, depending on the system configuration.
- Buffer Compatibility: Supports various aqueous and organic buffers used in protein purification.
- Protein Type: Designed for the purification of proteins, peptides, nucleic acids, and other biomolecules.
- Column Compatibility: Compatible with a broad range of chromatography columns, including pre-packed and custom-packed columns for various applications.
Thermo Scientific NanoDrop OneC
Manufacturer
Thermo Fisher Scientific
Model
NanoDrop OneC
Service Type
Protein Production
Specifications
- Wavelength Range: 190 nm to 850 nm
- Measurement Range:
- Nucleic acids: 2 ng/µL to 15,000 ng/µL (dsDNA)
- Proteins: 0.06 mg/mL to 400 mg/mL (BSA)
- Absorbance Accuracy: ± 3% (at 0.97 absorbance at 302 nm)
- Sample Volume: 1 µL to 2 µL (microvolume pedestal) and 0.5 mL to 2 mL (cuvette mode)
- Measurement Time: Approximately 8 seconds per sample
- Cuvette Compatibility: Standard 10 mm pathlength cuvettes
- Operating Temperature: 10°C to 35°C
Application
The Thermo Scientific NanoDrop OneC is a versatile microvolume UV-Vis spectrophotometer designed for the quantification and analysis of nucleic acids, proteins, and other biomolecules. The OneC model includes both microvolume and cuvette capabilities, making it an ideal tool for labs that need flexibility in sample measurement. With its patented sample retention technology, the NanoDrop OneC requires minimal sample volume for accurate readings, reducing waste and preserving precious samples. The built-in touchscreen interface simplifies operation, while advanced software features such as contaminant analysis and spectral viewing enable comprehensive data analysis. This instrument is widely used in molecular biology, biochemistry, and proteomics research.
Recommended Sample Requirements
Invitrogen iBright 1500
Manufacturer
Invitrogen (Thermo Fisher Scientific)
Model
iBright 1500
Service Type
Protein Production
Specifications
- Detection Method: Fluorescence and chemiluminescence imaging
- Imaging Area: 22.5 x 18.0 cm
- Resolution: Up to 9.1 megapixels
- Excitation Sources: RGB LED-based system with multiple wavelength options
- Emission Filters: Automated filter wheel with interchangeable filters
- Dynamic Range: 4.8 OD
- Sensitivity: Detects low-femtogram levels of protein in chemiluminescence mode
- Touchscreen Display: 12.1-inch color touchscreen for instrument control and image preview
- Software: iBright Analysis Software with cloud connectivity for data analysis and sharing
Application
The Invitrogen iBright 1500 is an advanced imaging system designed for the detection and analysis of fluorescence and chemiluminescence signals in a variety of applications, including Western blotting, nucleic acid gels, and protein assays. The iBright 1500 offers high sensitivity and a broad dynamic range, allowing researchers to capture low-abundance signals with exceptional clarity. Its user-friendly touchscreen interface, combined with powerful image analysis software, simplifies the workflow from image acquisition to data interpretation. The instrument’s multiple excitation and emission options make it versatile for various fluorescent dyes and chemiluminescent substrates, providing reliable and reproducible results.
Recommended Sample Requirements
- Sample Type: Suitable for protein gels, nucleic acid gels, and membranes used in Western blotting and other assays.
- Fluorophore Compatibility: Compatible with a wide range of fluorescent dyes, including Alexa Fluor, SYBR Green, and ethidium bromide.
- Chemiluminescent Substrates: Optimized for popular chemiluminescent substrates like ECL, SuperSignal, and others.
- Gel/Blot Size: Designed for imaging standard gels and membranes up to 22.5 x 18.0 cm.
Thermo Scientific Sorvall LYNX 6000
Manufacturer
Thermo Scientific
Model
Sorvall LYNX 6000
Service Type
Protein Production
Specifications
- Maximum Speed: 29,000 RPM
- Maximum RCF: 100,605 x g
- Maximum Capacity: 6 liters (with appropriate rotor)
- Rotor Compatibility: Wide range of fixed-angle, swinging-bucket, and specialty rotors
- Temperature Range: -10°C to +40°C
Application
The Thermo Scientific Sorvall LYNX 6000 is a high-performance superspeed centrifuge designed for a broad range of applications, from cellular research to bioprocessing. With its advanced rotor management system, the Sorvall LYNX 6000 offers unmatched versatility and safety, enabling rapid changes between different rotors without the need for tools. The system’s powerful refrigeration capabilities maintain precise temperature control, making it ideal for temperature-sensitive samples. The intuitive touchscreen interface allows for easy setup and monitoring, while the high-speed capabilities ensure fast and efficient separations of particles, cells, organelles, and macromolecules.
Recommended Sample Requirements
Thermo Scientific Titan Krios G3i
Manufacturer
Thermo Scientific
Model
Titan Krios G3i
Service Type
cryo-EM
Specifications
- Electron Source: XFEG (eXtended Field Emission Gun)
- Acceleration Voltage: 80-300 kV
- Resolution: Sub-angstrom (up to 1.2 Å)
- Magnification Range: 20x to 1,500,000x
- Detection System: Direct Electron Detector (DED) with high frame rate for cryo-EM
- Cryo System: Automated cryo-transfer system with autoloader for up to 12 grids
- Stage Type: High-precision piezo stage with sub-nanometer stability
- Software: EPU (Automated Data Acquisition), CFEG, and Thermo Scientific Tomography 4.0
Application
The Thermo Scientific Titan Krios G3i is one of the most advanced cryo-electron microscopes (cryo-EM) available, designed for high-resolution structural biology studies. The Titan Krios G3i offers unprecedented levels of automation, stability, and resolution, making it the preferred tool for elucidating the structures of macromolecular complexes, viruses, and other biological specimens at near-atomic resolution. With its powerful electron source, direct electron detection, and advanced automation, the Titan Krios G3i enables researchers to acquire large datasets for single-particle analysis, cryo-electron tomography, and other demanding cryo-EM applications with maximum efficiency and precision.
Recommended Sample Requirements
- Sample Type: Ideal for biological specimens, including proteins, nucleic acids, viruses, and cellular organelles.
- Grid Type: Compatible with standard TEM grids (gold, copper, molybdenum) prepared using cryo-EM techniques.
- Sample Preparation: Requires vitrified samples prepared under cryogenic conditions to prevent ice crystal formation.
- Temperature Control: Maintains cryogenic temperatures (below -180°C) throughout the imaging process to preserve sample integrity.
- Sample Size: Suitable for nanometer to micrometer-sized specimens.
Thermo Scientific Glacios Cryo-TEM
Manufacturer
Thermo Scientific
Model
Glacios Cryo-TEM
Service Type
cryo-EM
Specifications
- Electron Source: XFEG (eXtended Field Emission Gun)
- Acceleration Voltage: 80-200 kV
- Resolution: Sub-nanometer resolution (up to 2.5 Å)
- Magnification Range: 28x to 350,000x
- Detection System: Direct Electron Detector (DED) with high frame rate for cryo-EM
- Cryo System: Automated cryo-transfer system with autoloader for up to 12 grids
- Stage Type: High-precision piezo stage with cryo-stability
- Software: EPU (Automated Data Acquisition), Tomography 4.0, and advanced image processing tools
Application
The Thermo Scientific Glacios Cryo-TEM is a high-performance, user-friendly cryo-electron microscope designed to streamline and accelerate structural biology research. The Glacios offers a powerful and cost-effective solution for cryo-EM studies, providing high-resolution imaging capabilities in a more accessible platform compared to larger instruments like the Titan Krios. Equipped with an XFEG electron source, direct electron detection, and advanced automation features, the Glacios is ideal for single-particle analysis, cryo-electron tomography, and other structural biology applications. Its robust design and ease of use make it a popular choice for both core facilities and individual research labs.
Recommended Sample Requirements
- Sample Type: Optimized for biological specimens, including proteins, nucleic acids, viruses, and cellular structures.
- Grid Type: Compatible with standard cryo-TEM grids (copper, gold, molybdenum) for vitrified samples.
- Sample Preparation: Requires samples to be vitrified using cryo-EM techniques to avoid ice crystal formation.
- Temperature Control: Maintains cryogenic temperatures (below -180°C) to ensure sample preservation during imaging.
- Sample Size: Suitable for specimens ranging from nanometers to micrometers in size.
Thermo Scientific VolumeScope 2 SEM
Manufacturer
Thermo Scientific
Model
VolumeScope 2 SEM
Service Type
cryo-EM
Specifications
- Electron Source: Schottky Field Emission Gun (FEG)
- Acceleration Voltage: 200V to 30 kV
- Resolution: Down to 1.0 nm at 30 kV
- Magnification Range: 20x to 1,000,000x
- Imaging Modes: Secondary Electron (SE), Backscattered Electron (BSE), Energy Dispersive X-ray Spectroscopy (EDS)
- Stage: 5-axis motorized stage with high-precision control
- Imaging Area: Large field of view with nanoscale resolution
- Software: Thermo Scientific Avizo and Amira for 3D visualization and analysis
Application
The Thermo Scientific VolumeScope 2 SEM is an advanced scanning electron microscope (SEM) designed for high-resolution 3D imaging and analysis of biological and materials science samples. The VolumeScope 2 SEM excels in creating detailed 3D reconstructions at the nanoscale, making it a powerful tool for structural biology, materials research, and nanotechnology. With its high-resolution imaging capabilities, large field of view, and advanced detection systems, the VolumeScope 2 SEM is ideal for exploring complex sample morphologies, material compositions, and microstructures. The integrated software for 3D visualization and analysis enables comprehensive data interpretation, making it a versatile instrument for both research and industrial applications.
Recommended Sample Requirements
- Sample Type: Suitable for a wide range of biological and materials science samples, including cells, tissues, polymers, metals, and semiconductors.
- Sample Preparation: Samples may require coating with a conductive material (e.g., gold or platinum) depending on the analysis mode.
- Size Compatibility: Can accommodate samples up to several centimeters in size, with precise imaging down to the nanoscale.
- Temperature Stability: Samples should be stable under vacuum conditions during SEM imaging.
Thermo Scientific Aquilos 2 FIB/SEM
Manufacturer
Thermo Scientific
Model
Aquilos 2 FIB/SEM
Service Type
cryo-EM
Specifications
- Electron Source: Schottky Field Emission Gun (FEG)
- Ion Source: Gallium Liquid Metal Ion Source (LMIS)
- Acceleration Voltage (SEM): 500V to 30 kV
- Acceleration Voltage (FIB): 2 kV to 30 kV
- Resolution (SEM): Down to 1.0 nm at 30 kV
- Resolution (FIB): Down to 7 nm at 30 kV
- Magnification Range: 500x to 2,000,000x
- Cryo Capabilities: Integrated cryo-stage for cryo-FIB milling and cryo-SEM imaging
- Stage: 5-axis motorized stage with cryo-compatibility
- Software: Thermo Scientific AutoScript 4 and MAPS software for automated milling and imaging
Application
The Thermo Scientific Aquilos 2 FIB/SEM is a state-of-the-art dual-beam system specifically designed for cryo-electron microscopy (cryo-EM) applications. Combining focused ion beam (FIB) milling with scanning electron microscopy (SEM), the Aquilos 2 enables researchers to prepare and image thin lamellae of biological samples at cryogenic temperatures, preserving their native structure. This system is essential for structural biology studies, where it allows for precise milling and imaging of vitrified samples, leading to high-resolution 3D reconstructions. The Aquilos 2’s advanced cryo-capabilities and automation tools make it a powerful instrument for exploring cellular architecture and macromolecular complexes in unprecedented detail.
Recommended Sample Requirements
- Sample Type: Optimized for biological specimens, including cells, tissues, and macromolecular complexes that require cryo-EM preparation.
- Sample Preparation: Samples must be vitrified and maintained at cryogenic temperatures during milling and imaging.
- Grid Type: Compatible with standard cryo-EM grids used in FIB milling and cryo-SEM imaging.
- Cryo-Conditions: Operates under cryogenic conditions, ensuring that samples remain in their vitrified state throughout the process.
- Sample Size: Suitable for subcellular and nanoscale sample preparation and imaging.
Raise3D Pro
Manufacturer
Raise3D
Model
Pro2 / Pro2 Plus
Service Type
X-ray Crystallography
Specifications
- Build Volume: 12 x 12 x 11.8 inches (305 x 305 x 300 mm)
- Layer Resolution: 0.01 mm (10 microns) to 0.25 mm (250 microns)
- Extruder Type: Dual-extrusion with independent nozzle height adjustment
- Nozzle Diameter: 0.4 mm (standard), with options from 0.2 mm to 1.0 mm
- Maximum Nozzle Temperature: 300°C (572°F)
- Build Plate Temperature: Up to 110°C (230°F)
- Print Speed: 30 to 150 mm/s
- Filament Compatibility: PLA, ABS, PETG, TPU, Nylon, Carbon Fiber Reinforced, Metal Composites, and more
Application
The Raise3D Pro series (Pro2 and Pro2 Plus) is a high-performance, professional-grade 3D printer designed for a wide range of applications, from prototyping to small-scale manufacturing. The Pro series features a dual-extrusion system, enabling multi-material or multi-color prints with precise nozzle height adjustment. The fully enclosed design, along with a heated build plate and HEPA air filtration, ensures stable printing conditions and enhanced safety when working with a variety of filament types, including advanced materials like carbon fiber composites. With its user-friendly touchscreen interface and versatile connectivity options, the Raise3D Pro series is well-suited for professional environments where reliability, precision, and flexibility are essential.
Recommended Sample Requirements
VWR 20°C Incubator (Cat: 89511-420)
Manufacturer
VWR International
Model
Service Type
X-ray Crystallography
Specifications
- Catalog Number: 89511-420
- Temperature Range: Fixed at 20°C (±0.5°C)
- Internal Volume: 2.5 cubic feet (70 liters)
- Internal Dimensions: 17.3 x 15.4 x 16.4 inches (44 x 39 x 41.7 cm)
- External Dimensions: 25 x 24 x 22 inches (63.5 x 61 x 56 cm)
- Shelves: 2 adjustable shelves, with the capacity to add more
- Temperature Uniformity: ±0.5°C at 20°C
Application
The VWR 20°C Incubator (Cat: 89511-420) is a specialized incubator designed to maintain a consistent temperature of 20°C, making it ideal for applications that require stable ambient conditions. This incubator is commonly used in laboratories for sample storage, microbiology testing, plant cell culture, and other processes where precise temperature control at 20°C is critical. The incubator’s compact design and adjustable shelving allow for efficient use of space, while the digital control system ensures reliable and accurate temperature maintenance. The solid, insulated door helps to minimize temperature fluctuations, contributing to the overall stability of the environment inside the incubator.
Recommended Sample Requirements
VWR 4°C Incubator
Manufacturer
VWR International
Model
HCUCFS0504G
Service Type
X-ray Crystallography
Specifications
- Temperature Range: 2°C to 10°C (factory set to 4°C)
- Internal Volume: 4.9 cubic feet (138 liters)
- Internal Dimensions: 20 x 17 x 25 inches (51 x 43 x 64 cm)
- External Dimensions: 24 x 24 x 33 inches (61 x 61 x 84 cm)
- Shelves: 3 adjustable shelves, with the capacity to add more
- Temperature Uniformity: ±0.5°C at 4°C
Application
The VWR 4°C Incubator (Model: HCUCFS0504G) is a precision-controlled refrigerated incubator designed for applications that require consistent low-temperature environments. The incubator maintains a stable temperature range between 2°C and 10°C, with a factory setting of 4°C, making it ideal for storing temperature-sensitive samples such as biological reagents, culture media, vaccines, and other perishable items. The unit’s forced-air cooling system ensures uniform temperature distribution throughout the chamber, while the digital control system allows for precise temperature adjustments. The incubator’s compact size and adjustable shelving make it suitable for various laboratory settings, offering both flexibility and reliability in sample storage.
Recommended Sample Requirements
Fisher Scientific Sonicator
Manufacturer
Fisher Scientific
Model
FB505
Service Type
Protein Production
Specifications
- Power Output: 500 watts
- Frequency: 20 kHz
- Amplitude Range: 20% to 100% (adjustable)
- Pulse Mode: 1 second to 10 minutes on/off cycles
- Temperature Monitoring: Optional temperature probe available
- Timer: 1 second to 10 hours
- Display: Digital control with LCD display
- Probe Options: Compatible with a variety of probe sizes (1/8” to 1” diameter)
Application
The Fisher Scientific Sonicator (Model: FB505) is a powerful ultrasonic homogenizer designed for the disruption of cells, emulsification, and other applications requiring high-intensity ultrasonic energy. With a power output of 500 watts and a frequency of 20 kHz, the FB505 can efficiently break down cells, shear DNA, and disperse particles in a variety of samples. The instrument features adjustable amplitude and pulse mode, allowing for precise control over the sonication process. The optional temperature probe ensures that samples can be monitored and maintained within a specific temperature range, preventing overheating during extended sonication. The FB505 is commonly used in molecular biology, nanotechnology, and materials science research.
Recommended Sample Requirements
Eppendorf Innova S44i
Manufacturer
Eppendorf
Model
Innova S44i
Service Type
Protein Production
Specifications
- Type: Stackable Incubator Shaker
- Temperature Range: 4°C to 80°C
- Shaking Speed: 25 to 400 RPM (±1 RPM)
- Orbit Diameter: 1.9 cm (0.75 inches)
- Maximum Capacity: Erlenmeyer Flasks: Up to 23 x 2 L, 15 x 3 L, or 12 x 4 L
- Microplates: Up to 84 standard microplates or 42 deep-well plates
Application
The Eppendorf Innova S44i is a high-capacity, stackable incubator shaker designed for efficient and reliable culturing of microbial and eukaryotic cells. With its wide temperature range and robust shaking capabilities, the Innova S44i is ideal for a variety of applications, including protein expression, fermentation, and cell growth studies. The instrument’s advanced control system allows for precise regulation of temperature, speed, and humidity, while the stackable design maximizes laboratory space. The full-color touchscreen interface and VisioNize software integration enable easy programming, data logging, and remote monitoring, making the Innova S44i a versatile and user-friendly solution for large-scale cell culture needs.
Recommended Sample Requirements
New Brunswick Innova 44
Manufacturer
Eppendorf (New Brunswick Scientific)
Model
Innova 44
Service Type
Protein Production
Specifications
- Type: Benchtop Incubator Shaker
- Temperature Range: 5°C above ambient to 80°C
- Shaking Speed: 25 to 400 RPM (±1 RPM)
- Orbit Diameter: 1.9 cm (0.75 inches)
- Maximum Capacity:
- Erlenmeyer Flasks: Up to 15 x 1 L, 9 x 2 L, or 6 x 4 L flasks
- Microplates: Up to 36 standard microplates
Application
The New Brunswick Innova 44 is a versatile benchtop incubator shaker designed for the reliable and efficient culturing of microbial and eukaryotic cells. The Innova 44 features a broad temperature range, allowing for a wide variety of experimental conditions, including protein expression, fermentation, and cell growth studies. The shaker’s robust design and precise control of temperature and speed ensure consistent results, while the option to add CO2 and humidity control modules makes it suitable for even the most sensitive cultures. The stackable design allows for space-saving in the lab, making it a practical choice for researchers who require high-throughput capabilities.
Recommended Sample Requirements
Kewaunee Scientific The Interceptor
Manufacturer
Kewaunee Scientific Corporation
Model
INT-2000
Service Type
Protein Production
Specifications
- Type: Class II Type A2 Biosafety Cabinet (Tissue Culture Hood)
- Airflow: Vertical laminar airflow with 70% recirculated and 30% exhausted
- HEPA Filters: 99.99% efficient at 0.3 microns for supply and exhaust
- UV Light: Integrated UV-C germicidal lamp for decontamination
Application
The Kewaunee Scientific Corporation The Interceptor (Model: INT-2000) is a Class II Type A2 biosafety cabinet designed to provide a sterile and safe environment for tissue culture work, handling pathogenic materials, and other sensitive biological procedures. The Interceptor features vertical laminar airflow, which ensures a continuous flow of HEPA-filtered air across the work surface, protecting both the user and the samples from contamination. The cabinet is equipped with microprocessor controls for easy operation and monitoring of critical parameters, including airflow and filter status. The integrated UV-C germicidal lamp provides an additional layer of decontamination, making the INT-2000 an essential tool for laboratories working with cell cultures, microbiology, and other life science applications.
Recommended Sample Requirements
Nexcelom Bioscience Cellometer Auto2000
Manufacturer
Nexcelom Bioscience
Model
Cellometer Auto2000
Service Type
Protein Production
Specifications
- Detection Method: Brightfield and fluorescence microscopy
- Sample Volume: 20 µL to 40 µL per measurement
- Cell Types Supported: Mammalian cells, PBMCs, primary cells, stem cells, yeast, and more
- Concentration Range: 5 x 10^4 to 1 x 10^7 cells/mL
- Measurement Time: Approximately 10 seconds per sample
- Fluorescent Channels: Dual fluorescence channels (e.g., AO/PI) for viability assessment
- Data Output: Cell count, viability, concentration, cell size distribution
Application
The Nexcelom Bioscience Cellometer Auto2000 is an automated cell counter designed for fast and accurate cell counting and viability analysis. The Auto2000 uses both brightfield and dual-fluorescence imaging to provide comprehensive data on cell concentration, viability, and size distribution. It is particularly useful for researchers working with primary cells, mammalian cells, and other challenging samples where accurate viability assessment is critical. The user-friendly touchscreen interface and integrated software allow for easy operation and data management, making the Auto2000 a valuable tool for routine cell culture work, drug development, and other cell-based assays.
Recommended Sample Requirements
Eppendorf Centrifuge 5810R
Manufacturer
Eppendorf
Model
5810R
Service Type
Protein Production
Specifications
- Type: Refrigerated Bench-Top Centrifuge
- Maximum Speed: 14,000 RPM
- Maximum RCF: 20,913 x g
- Maximum Capacity:
- Swing-bucket rotor: Up to 4 x 500 mL
- Fixed-angle rotor: Up to 6 x 85 mL or 48 x 1.5/2.0 mL microcentrifuge tubes
- Temperature Range: -9°C to +40°C
- Acceleration/Deceleration Profiles: 10 acceleration and 10 deceleration profiles
- Rotor Compatibility: Supports a wide range of rotors including swing-bucket, fixed-angle, and plate rotors
Application
The Eppendorf Centrifuge 5810R is a versatile and powerful refrigerated bench-top centrifuge designed for a wide range of applications in molecular biology, cell culture, and clinical laboratories. With its high capacity and broad temperature range, the 5810R is ideal for processing large volumes of samples while maintaining precise temperature control, making it suitable for temperature-sensitive samples. The centrifuge’s intuitive digital interface allows for easy programming and monitoring of speed, time, and temperature settings. Its ability to accommodate various rotors and adapters makes it a flexible solution for laboratories that require efficient and reliable centrifugation.
Recommended Sample Requirements
Eppendorf Centrifuge 5430R
Manufacturer
Eppendorf
Model
5430R
Service Type
Protein Production
Specifications
- Type: Refrigerated Microcentrifuge
- Maximum Speed: 17,500 RPM
- Maximum RCF: 30,130 x g
- Temperature Range: -11°C to +40°C
- Rotor Compatibility: Supports a wide range of rotors, including fixed-angle, swing-bucket, and plate rotors
Application
The Eppendorf Centrifuge 5430R is a compact, high-performance refrigerated microcentrifuge designed for a wide range of applications in molecular biology, biochemistry, and clinical research. Despite its small footprint, the 5430R offers high-speed centrifugation with the flexibility to accommodate various rotors for different tube sizes and microplates. The refrigeration system maintains temperatures as low as -11°C, ensuring that temperature-sensitive samples are protected during centrifugation. The centrifuge’s intuitive digital interface allows for easy programming and monitoring, making it an essential tool for labs requiring precise and reliable sample preparation.
Recommended Sample Requirements
Thermo Scientific TSX 60086A
Manufacturer
Thermo Fisher Scientific
Model
TSX 60086A
Service Type
Protein Production
Specifications
- Type: Ultra-Low Temperature Freezer (Upright)
- Temperature Range: -50°C to -86°C
- Capacity: 27.8 cubic feet (785 liters)
Application
The Thermo Scientific TSX 60086A is an ultra-low temperature (ULT) freezer designed for long-term storage of biological samples, including DNA, RNA, proteins, and cell cultures. The TSX series is known for its energy efficiency and precise temperature control, thanks to the innovative V-drive technology, which adjusts cooling performance based on usage patterns to reduce energy consumption while maintaining uniform temperature stability. The freezer’s large capacity and flexible shelving make it suitable for high-density storage of valuable and temperature-sensitive samples. The microprocessor control system provides real-time monitoring and alarms to ensure sample safety, making the TSX 60086A an ideal choice for research laboratories, biobanks, and clinical applications.
Recommended Sample Requirements
BIO-RAD GenePulser Xcell
Manufacturer
BIO-RAD
Model
GenePulser Xcell
Service Type
Protein Production
Specifications
- Type: Electroporation System
- Pulse Type: Exponential decay and square wave
- Voltage Range:
- Exponential Decay: 50 V to 3,000 V
- Square Wave: 5 V to 500 V
- Capacitance Range: 0.05 µF to 3,275 µF
- Resistance Range: 50 Ω to 1,000 Ω (for exponential decay)
- Pulse Length: 10 µs to 3,000 µs (for square wave)
- Cuvette Compatibility: 0.1 cm, 0.2 cm, and 0.4 cm gap electroporation cuvettes
Application
The BIO-RAD GenePulser Xcell is a versatile electroporation system designed for the efficient transfection of a wide variety of cell types, including bacterial, yeast, plant, and mammalian cells. The system offers both exponential decay and square wave pulse options, allowing for optimization based on the specific requirements of different cell types and applications. The GenePulser Xcell is commonly used in genetic engineering, gene expression studies, and molecular biology research for the introduction of DNA, RNA, or other molecules into cells. Its digital display and user-friendly interface simplify the setup and monitoring of electroporation parameters, ensuring consistent and reliable results.
Recommended Sample Requirements
- Cell Type: Suitable for a wide range of cell types, including bacteria, yeast, plant protoplasts, and mammalian cells.
- Cuvette Size: Compatible with 0.1 cm, 0.2 cm, and 0.4 cm gap electroporation cuvettes, depending on the cell type and electroporation protocol.
- Buffer Compatibility: Works with standard electroporation buffers optimized for different cell types.
- Sample Volume: Typically accommodates volumes ranging from 20 µL to 800 µL, depending on the cuvette used.
Thermo Scientific MiniAmp Thermal Cycler
Manufacturer
Thermo Fisher Scientific
Model
MiniAmp
Service Type
Protein Production
Specifications
- Type: Thermal Cycler (PCR Machine)
- Block Format: 96-well, standard PCR plate format
- Temperature Range: 4°C to 99°C
- Temperature Accuracy: ±0.25°C
- Temperature Uniformity: ±0.5°C well-to-well (at 90°C)
- Ramp Rate: Up to 3.0°C per second
- Gradient Capability: Yes, with 8-zone gradient function
Application
The Thermo Scientific MiniAmp Thermal Cycler is a compact and versatile PCR machine designed for everyday laboratory use. Despite its small footprint, the MiniAmp delivers precise temperature control and fast ramp rates, making it ideal for a wide range of PCR applications, including genotyping, cloning, and gene expression analysis. The 96-well block format is compatible with standard PCR plates and tubes, offering flexibility for different experimental needs. The instrument features a gradient capability that allows for the optimization of annealing temperatures across a range of wells, streamlining protocol development. The user-friendly touchscreen interface simplifies programming and operation, while the compact design makes it suitable for labs with limited bench space.
Recommended Sample Requirements
- Sample Type: Suitable for DNA, cDNA, and RNA amplification in PCR applications.
- Well Format: Compatible with 96-well PCR plates, 0.2 mL PCR tubes, and tube strips.
- Reaction Volume: Typically accommodates reaction volumes of 10-100 µL per well.
- Temperature Sensitivity: Ideal for protocols requiring precise temperature control and uniformity across all wells.
Thermo Scientific iBlot 2
Manufacturer
Thermo Fisher Scientific
Model
iBlot 2
Service Type
Protein Production
Specifications
- Type: Dry Blotting System
- Blotting Time: 7 minutes for standard proteins, 6 minutes for high molecular weight proteins
- Gel Compatibility: Mini, midi, and e-PAGE gels
- Membrane Compatibility: Nitrocellulose, PVDF
- Voltage Settings: Multiple preset voltage settings for different protein sizes (low, medium, high)
- Membrane Size: Up to 8 x 9 cm
- Display: LCD touchscreen interface for easy operation and protocol selection
- Blotting Capacity: Up to 2 mini gels or 1 midi gel per run
Application
The Thermo Scientific iBlot 2 Dry Blotting System is a fast and efficient tool designed to transfer proteins from polyacrylamide gels to membranes for subsequent immunodetection (Western blotting). The iBlot 2 system uses a dry, disposable blotting stack, eliminating the need for traditional wet transfer buffers and messy setups. With preset and customizable protocols, the iBlot 2 allows researchers to achieve consistent and reliable protein transfers in just a few minutes, significantly reducing blotting time compared to traditional methods. The system’s compact design and ease of use make it ideal for laboratories performing routine protein analysis, offering a reliable solution for quick and effective Western blot transfers.
Recommended Sample Requirements
- Sample Type: Suitable for protein samples separated by SDS-PAGE or native PAGE.
- Gel Types: Compatible with mini, midi, and e-PAGE gels, with the flexibility to accommodate different gel sizes.
- Membrane Types: Works with both nitrocellulose and PVDF membranes for a variety of Western blotting applications.
- Blotting Capacity: Designed for the efficient transfer of proteins from up to two mini gels or one midi gel per run.
Thermo Scientific iBind
Manufacturer
Thermo Fisher Scientific
Model
iBind
Service Type
Protein Production
Specifications
- Type: Automated Western Blot Processing System
- Compatible Membranes: Nitrocellulose, PVDF
- Membrane Size: Up to 8 x 8 cm
- Processing Steps: Blocking, primary antibody incubation, secondary antibody incubation, and washes
- Processing Time: Approximately 2.5 hours for a complete run
- Reagent Volume: 2.5 mL per channel (4 channels)
Application
The Thermo Scientific iBind is an automated, hands-free Western blot processing system designed to streamline the workflow for antibody incubation and washing steps. The iBind system uses passive fluidics, driven by sequential lateral flow, to automatically perform all the steps required for Western blot processing. This system ensures consistent results and reduces variability compared to manual blot processing. The iBind system is particularly useful for labs looking to simplify and standardize their Western blot workflows while freeing up time for other tasks. The compact design and ease of use make the iBind a convenient tool for efficient and reproducible Western blot processing.
Recommended Sample Requirements
- Sample Type: Suitable for protein samples transferred onto nitrocellulose or PVDF membranes.
- Membrane Size: Accommodates membranes up to 8 x 8 cm, making it ideal for mini gels and standard Western blot formats.
- Antibody Requirements: Requires standard primary and secondary antibodies for Western blotting; reagent volume is 2.5 mL per channel.
- Blotting Process: Designed for complete Western blot processing, including blocking, antibody incubation, and washes.
Tuttnauer Model: 5596-1VSP
Manufacturer
Tuttnauer
Model
5596-1VSP
Service Type
Protein Production
Specifications
- Type: Large Capacity Vertical Steam Sterilizer (Autoclave)
- Chamber Volume: 129 gallons (489 liters)
- Chamber Dimensions: 26 x 26 x 39 inches (66 x 66 x 99 cm)
- External Dimensions: 40 x 55 x 83 inches (102 x 140 x 211 cm)
- Temperature Range: 105°C to 138°C (221°F to 280°F)
- Pressure Range: 15 to 31 PSI (1.05 to 2.1 bar)
- Sterilization Cycles: Pre-vacuum, gravity, liquid, and special cycles for various applications
- Vacuum System: Multiple pre- and post-vacuum stages for air removal and drying
Application
The Tuttnauer Model 5596-1VSP is a large capacity vertical steam sterilizer (autoclave) designed for the sterilization of laboratory instruments, glassware, media, and other materials. With a chamber volume of 129 gallons (489 liters), this autoclave is ideal for high-throughput laboratories, research facilities, and production environments that require efficient and reliable sterilization of large batches of materials. The advanced control system allows for precise programming and monitoring of sterilization cycles, ensuring consistent and effective sterilization. The 5596-1VSP features multiple pre- and post-vacuum stages to enhance air removal and drying, making it suitable for a wide range of applications, including sterilizing porous loads and liquids.
Recommended Sample Requirements
Thermo Fisher Scientific Grid Clipping Station
Manufacturer
Thermo Fisher Scientific
Model
Grid Clipping Station
Service Type
cryo-EM
Specifications
- Type: Manual/Automated Grid Clipping Tool for Cryo-EM
- Function: Designed for clipping and preparing cryo-EM grids for use in cryo-electron microscopes
Application
The Thermo Fisher Scientific Grid Clipping Station is a specialized tool designed for the precise and contamination-free preparation of cryo-EM grids before they are loaded into cryo-electron microscopes, such as the Titan Krios, Glacios, or Aquilos systems. This station allows researchers to securely attach TEM grids to Autogrid rings, a crucial step in cryo-EM sample preparation. By ensuring consistent and accurate grid clipping, the station helps maintain the integrity of delicate cryo-EM samples, reducing the risk of grid damage and sample loss. This tool is essential in high-throughput cryo-EM labs where efficiency and sample quality are paramount.
Recommended Sample Requirements
Miele PG 8583
Manufacturer
Miele
Model
PG 8583
Service Type
Protein Production
Specifications
- Type: Laboratory Glassware Washer
- Capacity: Up to 128 laboratory glassware items per load (depending on item size and arrangement)
- Wash Programs: 11 standard programs, customizable cycles for specific laboratory glassware
- Temperature Range: Up to 93°C for thermal disinfection
- Drying System: Integrated drying system with HEPA-filtered airflow
Application
The Miele PG 8583 is a high-performance laboratory glassware washer designed for efficient and thorough cleaning of various laboratory items, such as beakers, flasks, pipettes, and test tubes. With its advanced cleaning technology, customizable wash programs, and thermal disinfection capabilities, this washer ensures the reliable removal of chemical residues, contaminants, and microorganisms. The integrated HEPA-filtered drying system ensures that glassware is clean, dry, and ready for immediate use. The PG 8583 is ideal for laboratories where consistent, high-throughput cleaning of sensitive glassware is critical for maintaining sample integrity and preventing contamination.
Recommended Sample Requirements
Sartorius Biostat A
Manufacturer
Sartorius
Model
Biostat A
Service Type
Protein Production
Specifications
- Type: Benchtop Bioreactor/Fermentor
- Working Volume:
- Single-use Vessel: 250 mL to 2 L
- Glass Vessel: 1 L to 2 L
- Control System: Integrated touchscreen interface with real-time monitoring and control
- Agitation: Magnetically coupled drive, 50 to 1,500 RPM
- Temperature Control: Integrated heating jacket, 10°C above ambient to 60°C
- pH Control: Automatic, via peristaltic pumps for acid/base addition
- DO Control: Automatic, with gas mixing (air, O2, N2, CO2) and sparger
Application
The Sartorius Biostat A is a versatile benchtop bioreactor designed for small-scale fermentation and cell culture applications. It is ideal for research and development labs, offering precise control over critical bioprocess parameters such as pH, dissolved oxygen (DO), temperature, and agitation. The system supports both single-use and glass vessels, making it adaptable for different bioprocessing needs. The Biostat A is commonly used for the cultivation of microbial, mammalian, and plant cells, facilitating the production of proteins, antibodies, and other biomolecules. Its intuitive touchscreen interface and integrated data logging capabilities ensure ease of use and reliable process monitoring, making it an essential tool for bioprocess optimization and scale-up studies.
Recommended Sample Requirements
Endosafe nexgen PTS
Manufacturer
Charles River Laboratories
Model
Endosafe nexgen PTS
Service Type
Protein Production
Specifications
- Type: Portable Endotoxin Testing System
- Detection Method: Limulus Amebocyte Lysate (LAL) assay with chromogenic endpoint
- Cartridge Format: Single-use cartridges with pre-loaded LAL reagent and control standard endotoxin (CSE)
- Sample Volume: 25 µL per test
- Test Capacity: Capable of running up to 4 tests simultaneously
- Assay Time: Approximately 15 minutes per test
- Detection Range: 0.05 EU/mL to 10 EU/mL (Endotoxin Units per milliliter)
- Calibration: Automatic calibration with each cartridge using internal controls
Application
The Endosafe nexgen PTS (Portable Testing System) is a rapid, portable endotoxin testing system designed for the on-site, real-time detection of bacterial endotoxins in pharmaceutical products, medical devices, and biological samples. Using FDA-licensed Limulus Amebocyte Lysate (LAL) assay technology, the system provides quantitative endotoxin results within 15 minutes, ensuring compliance with industry standards for endotoxin levels. The nexgen PTS utilizes single-use cartridges that contain pre-loaded reagents, simplifying the testing process and minimizing the risk of contamination. Its portability and ease of use make it an ideal choice for laboratories, manufacturing environments, and field testing scenarios where quick and reliable endotoxin testing is critical.
Recommended Sample Requirements
- Sample Type: Suitable for testing aqueous solutions, including pharmaceutical products, medical device extracts, and biological fluids.
- Sample Volume: Requires 25 µL of sample per test.
- Endotoxin Concentration: Can accurately detect endotoxin concentrations ranging from 0.05 EU/mL to 10 EU/mL.
- Testing Environment: Ideal for use in both laboratory and field settings, offering flexibility for on-site testing and rapid results.
Thermo Scientific MAXQ 6000
Manufacturer
Thermo Fisher Scientific
Model
MAXQ 6000
Service Type
Protein Production
Specifications
- Type: Orbital Shaker
- Shaking Speed: 35 to 500 RPM
- Orbit Diameter: 1.9 cm (0.75 inches)
- Platform Size:
- Single-tier: 18 x 18 inches (46 x 46 cm)
- Double-tier: Additional tier available for increased capacity
- Load Capacity: Up to 35 lbs (15.9 kg) per platform
Application
The Thermo Scientific MAXQ 6000 is a versatile orbital shaker designed for a wide range of laboratory applications, including cell culture, protein expression, and general mixing. The MAXQ 6000 is available in both ambient and incubator models, offering flexibility for experiments requiring temperature control. Its large platform size and high load capacity make it suitable for handling multiple flasks, bottles, or trays simultaneously. The digital control system allows for precise regulation of shaking speed, time, and, in the incubator model, temperature, ensuring consistent and reproducible results. The MAXQ 6000 is ideal for laboratories that require robust and reliable mixing performance for their experiments.
Recommended Sample Requirements
Biophysical characterization Methods
CD (Circular Dichroism)
Instrument
Jasco J-715
Application
Rapid determination of the secondary structure and folding properties of proteins. Analyzes the secondary structure and conformational changes of biomolecules, such as proteins and nucleic acids, in solution.
MP (Mass Photometry)
Instrument
Refeyn / TwoMP
Application
Measures absolute mass of particles in solution and detects the ratio of different species (oligomeric states).
DLS (Dynamic Light Scattering)
Instrument
Malvern / Zetasizer Nano-S
Application
Measures particle size distributions, diffusion coefficients, and molecular weight information.
LC-MS (Mass Spectrometry)
Instrument
Thermo / Orbitrap Fusion Lumos
Application
Identifies and quantifies proteins in both simple and complex formats. Identification and mass measurement of molecules in samples.
SEC-MALS (SEC-Multi-Angle Light Scattering)
Instrument
Wyatt Technology / DAWN HELEOS II / OptiLab rEX
Application
Measures absolute molecular weight, size, and conformation of macromolecules in solution. Analyzes the absolute molar mass and size of macromolecules in solution, providing insights into their structure, aggregation, and interactions.
TSA (Thermal Shift Analysis)
Instrument
Thermo / QuantStudio3
Application
Measures thermal stability of target protein. Measures the stability and melting behavior of biomolecules under varying temperature conditions.
MST (Microscale Thermophoresis)
Instrument
NanoTemper / Monotlith NT.115 Blue/Red
Application
Quantification of biomolecular interaction strength (Kd). An immobilization-free technique for measuring biomolecular interactions.
BLI (Biolayer Interferometry)
Instrument
ForteBio / Octet K2
Application
Measures on/off rate of two molecules. BLI enables real-time analysis of biomolecular binding kinetics and affinity.
SPR (Surface Plasmon Resonance)
Instrument
Cytiva / Biacore T200 & 8K
Application
Measures on/off rate of two molecules. Analyzes biomolecular interactions in real-time, providing insights into binding kinetics, affinity, and specificity.
ITC (Isothermal Titration Calorimetry)
Instrument
TA Instruments / NanoITC
Application
Measures interaction of two molecules, including affinity (KA), enthalpy (ΔH), entropy (ΔS), and stoichiometry (n). A label-free method for measuring binding thermodynamics.